3D Cell culture Global Market estimated to be worth $2,867.1 million by 2028

Sep 13 - 2023

3D cell culture is an artificial environment that allows biological cells to interact with the environment in a three-dimensional way, similar to cells "in vivo". Cells in a 3D cell culture model are subjected to stimuli and environmental conditions similar to those encountered by the cells of a living organism. The close replication of real-world conditions in 3D cell culture models has made them increasingly becoming popular in variety of applications like tissue engineering, drug discovery, toxicity testing, disease modelling, cancer research, stem cell research and others. The development of advanced scaffold based products (ready to use scaffold based plates, organ specific scaffolds etc), scaffold free products (portable bioreactor, organ on chip etc., and emerging high potential bioprinting technologies will further expands the 3D cell culture applications areas.

The 3D Cell culture global market is expected to grow at a mid teen CAGR from 2021 to 2028. The factors such as increasing funding towards the cell based research, increasing focus towards the application 3D cell culture models in in-vitro testing in drug discovery, toxicity testing due to advantages over 2D cell culture system are driving the 3D cell culture market. Whereas, growing focus towards application of 3D cell culture in the personalized and regenerative medicine and advancement is 3D cell culture technologies such as advanced bioreactors (integrated bioreactor and hand handled bioreactor), magnetic bioprinting or levitation, organ specific scaffolds and integration of AI technologies will provide immense growth opportunities for the 3D cell culture market. However, lack of skilled personnel, complications associated with establishment of 3D cell culture, ethical issues associated with 3D cell culture and stringent process control for handling 3D cell culture expected to hamper the market growth.

The market for 3D cell culture is segmented based on technology, products, end-user and geography. Based on the technology, the market is segmented into scaffold based platforms, scaffold free platforms and bioprinting. Among technologies, Scaffold based platforms is accounted for the highest revenue in 2021 and is expected to grow at a low teen CAGR from 2021 to 2028. Scaffold free platforms is expected to grow at a mid teen CAGR from 2021 to 2028 due to increasing adoption of scaffold free technologies in the development of 3D models such as spheroids and development of advanced scaffold free products such as integrated bioreactor, organ-on chip etc. The scaffold based platforms is further segmented into solid scaffolds, hydrogels and others. Among these, Solid Scaffolds segment is accounted for the highest revenue in 2021 and is expected to grow at a low teen CAGR from 2021 to 2028. Hydrogels is expected to grow at a mid teen CAGR from 2021 due to increasing development of advanced hydrogels. The scaffold free platforms is further segmented into hanging drop method, agitation based method, forced floating and microfluidics. Among these, Forced floating segment is accounted for the highest revenue in 2021 and is expected to grow at a mid teen CAGR from 2021 to 2028. Microfluidics is expected to grow at a high teen CAGR from 2021 to 2028.

Based on the products, the 3D cell culture market is classified into Cells& tissues, Media, Sera and Reagents, Microplates & Others, assay kits, scaffolds and Instruments. Among the products, media, sera and reagents accounted for the highest revenue in 2021 and are expected to grow at a mid teen CAGR from 2021 to 2028 due to an increase in demand for media and reagents in research, and drug discovery applications. Scaffolds segment are expected to grow at a mid teen CAGR from 2021 to 2028 due to development of innovative scaffolds by the companies. Scaffold segment is further sub segmented into natural scaffolds, synthetic scaffolds and hybrid composite. Among these, Natural scaffolds segment is accounted for the highest revenue in 2021 and are expected to grow at a mid teen CAGR from 2021 to 2028. Synthetic Scaffolds segment is expected to grow at a mid teen CAGR from 2021 to 2028.

Based on applications the 3D cell culture market is divided into basic research, toxicity and drug safety screening, tissue engineering, stem cell research, drug discovery, cancer research, and others. Among the applications, cancer research accounted for the highest revenue in 2021 and is expected to grow at a mid teen CAGR from 2021 to 2028. Stem cell research is expected to grow at a mid teen CAGR from 2021 to 2028.

Based on end users, 3D cell culture market is segmented into academic and research institution, biotechnology and pharmaceutical industry, and others. Among these Biotechnology & Pharmaceutical segment is accounted for the highest revenue in 2021 and is expected to grow at a low teen CAGR from 2021 to 2028 due to increasing focus towards the adoption of 3D cell culture in-vitro models in drug discovery and toxicity testing applications and increase in development of new drugs. Other end-users such as CRO’s is expected to grow at a mid teen CAGR from 2021 to 2028 due to increasing focus towards the adoption of 3D cell culture model in drug discovery by the CRO’s.

By geography, the3D cell culture global market is segmented into North America (U.S. and Rest of North America), Europe (Germany, France, U.K. and Rest of Europe), Asia-Pacific (Japan, China, South Korea, and Rest of APAC) and the Rest of the world (Brazil, Rest of Latin America and the Middle East & Africa). North America accounted for the largest revenue in 2021 and is expected to grow at a low teen CAGR from 2021 to 2028. The factors increase in R&D expenditure, increasing government funding towards the cell based research, increasing drug discovery and development research and growing drug development pipelines, increasing interest towards the personalized medicine and regenerative medicine research and development of innovative 3D cell culture products by the companies for the application in research, drug discovery, and tissue engineering drivers the 3D cell culture market in the region.

Europe is expected to grow at a mid teen CAGR from 2021 to 2028.The factors such as increase in biotech R&D expenditure, presence of major biotech parks, entrepreneurship hubs with the ideal condition for biotech companies, venture capital providers, increasing number biotech companies, government funding for biotech innovative start-ups and cancer research stem cell research, growing drug discovery research by increasing investment in pharmaceutical sector to develop New Product Development (NPD) pipeline, development of advanced 3D cell culture products, entering of new companies with innovative 3D cell culture products and increase in private funding for the development of innovative 3D cell culture products are propelling  3D cell culture market in the region.

The 3D cell culture global market is competitive and all the players in this market are involved in adopting advanced technologies in 3D cell culture to expand their product portfolio and maintain their market shares. The key players in the 3D cell culture global market include Thermo Fisher Scientific (U.S.), Corning (U.S.), Lonza (Switzerland), Merck KGaA (Germany), Insphero (Switzerland), Reprocell (Japan), Greiner-Bio (Austria), Mimetas (Netherlands), Aspect Biosystem (Canada), BICO (Sweden) and 3D systems (U.S.).

The report provides an in-depth market analysis of the above-mentioned segments across the following region:

• North America

• U.S.
• Rest of North America

• Europe

• Germany
• U.K.
• France
• Rest of Europe

• Asia-Pacific 

• China
• Japan
• South Korea
• Rest of APAC

• Rest of the World (RoW)

• Brazil
• Rest of Latin America
• Middle East and Others